Crosslinked magnetic dextran nanoparticles  

are available with particle diameters of 300 nm and 500 nm for separation with a permanent magnet. Superparamagnetic dextran nanoparticles with particle diameters of 20 nm, 50 nm and 100 nm can not be separated with a conventional permanent magnet but in a high gradient magnetic field .

Crosslinked magnetic dextran nanoparticles  :

  • are prepared via the core-shell method with a core of magnetite and a dextran shell,

  • consist of 80-90% (w/w) magnetite in a matrix of crosslinked dextran (40.000 Da),

  • are designed with NH2, COOH, PEG-COOH or maleimide groups for the covalent binding of proteins, antibodies or other molecules,

  • are available with covalently bound streptavidin (or other proteins on request).

Crosslinked superparamagnetic dextran nanoparticles :

  • are prepared by precipitation of iron oxide in the presence of dextran,

  • consist of about 70-90% (w/w) iron oxide in a matrix of dextran (40.000 Da) in dependence on the diameter and surface modification,

  • differ in the size of the iron oxide domains for different diameters,

  • are preferably applied for detection purposes in magnetic resonance imaging or in magneto-immuno assays,

  • show good specific power absorption rates for hyperthermia applications for a particle diameter of 100 nm,

  • are designed with amino or maleimide groups for the covalent binding of proteins, antibodies or other molecules,

  • can be provided with covalently bound antibodies on request.