Magnetic silica particles

• are produced by hydrolysis of orthosilicates in the presence of magnetite,

• have a hydrophilic surface with terminal Si-OH-bonds,

• have monomodal size distributions,

• can easily be separated with conventional permanent magnets,

• are extremely stable in organic solvents and at high temperatures,

• are designed with the surface functionalities OH (plain), NH₂, COOH, SH, N-hydroxysuccinimide (NHS) and epoxy for the covalent binding of proteins, antibodies or other molecules,

• are available with covalently bound proteins (avidin, streptavidin, protein A, albumin) and biotin,

• can be offered with the nickel(II) chelator nitrilotriacetic acid (NTA) or ready to use with the corresponding nickel complex (Ni-NTA) for the binding of histidine labeled proteins,

• are available with a hydrophobic octadecyl (C18) surface,

• are deliverable with an organic polymer shell (core-shell method) on request.

Cluster-typed magnetic silica particles ( -CT)

• are produced by hydrolysis of orthosilicates in the presence of magnetite,

• show a homogeneous distribution of magnetite in the silica matrix by the special preparation method,

• have a hydrophilic surface with terminal Si-OH-bonds,

• can easily be separated even in highly viscous media with conventional permanent magnets,

• are extremely stable in organic solvents and at high temperatures,

• are designed with the surface functionalities OH (plain), NH₂, COOH and epoxy for the covalent binding of proteins, antibodies or other molecules,

• are available with covalently bound proteins (avidin, streptavidin, protein A, albumin),

• can be offered with the nickel(II) chelator nitrilotriacetic acid (NTA) or ready to use with the corresponding nickel complex (Ni-NTA) for the binding of histidine labeled proteins,

• are available with a hydrophobic octadecyl (C18) surface.